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found that cardiac KLF4 deficiency led to hyperacetylation of mitochondrial proteins, including SOD2, CypD, and long-chain Acyl-CoA dehydrogenase (LCAD), which impaired mitochondrial metabolic function and predisposed the CM-K4KO hearts to stress-induced dysfunction (Zhang et al., 2017)

Once these peptides pass through the BBB, they are thought to interact with opioid peptide receptors, thereby influencing neurotransmission (Pellissier et al